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For example, studies of healthy females found that the low level of serum folate in 677TT genotype is associated with an increase in homocysteine concentration and DNA hypomethylation 91,92 , which reveals the association between MTHFR C677T polymorphisms and nutrient status

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They slow stomach emptying, reduce appetite signals in the brain, and improve blood-sugar regulation which together typically lead to reduced calorie intake and weight loss under medical supervision